Inverse association between adiposity and telomere length: The Fels Longitudinal Study.
Lee M., et. al. Am J Hum Biol. 2011 Jan-Feb;23(1):100-6.
In a cross-sectional sample of 309 non-Hispanic white participants aged 8 to 80 yr (52% female), average telomere length was negatively correlated with age (r = -0.32, P < 0.0001) and had numerous significant correlations with established cardiovascular disease risk factors including waist circumference (r=- 0.33), apolipoprotein B (r=- 0.26), systolic blood pressure (r=- 0.28), and fasting serum glucose (r=- 0.15); all P < 0.0025. In backward selection linear regression models of telomere length, adiposity measures were consistently retained in the best models; BMI, waist circumference, hip circumference, total body fat, and visceral adipose tissue volume were all inversely associated with average telomere length at the nominal P < 0.05 level or lower, independent of age, sex, systolic blood pressure, and fasting serum lipid, lipoprotein, and glucose concentrations. Individuals with higher total and abdominal adiposity have lower average telomere length, a marker of cellular senescence, suggesting obesity may hasten the aging process.